Guillermo Garcia-Lopez
- Date of birth: June 4, 1983
- Birthplace: La Roda (Albacete), Spain
- Residence: Villena (Alicante), Spain
- Height: 6'2'' (1.87 m)
- Weight: 180 lbs (81 kg)
- Plays: Right-handed
Guillermo is good friends with fellow Spanish tennis player Juan Carlos Ferrero and both train at the JC Ferrero Equelite Tennis Academy in Villena, Spain.
On June 22, 2009, Garcia-Lopez achieved his career-high singles ranking: World No. 42. Garcia-Lopez lost to Roger Federer in 2R of Wimbledon 2009 2-6 2-6 4-6.
